Thermo Fisher Scientific TNFRSF8 Monoclonal Antibody (OTI18D3), TrueMAB
TNFRSF8 (CD30) 단백질을 표적으로 하는 마우스 단클론 항체로, Western blot, IHC, Flow cytometry에 적합합니다. Human 시료 반응성이 있으며, Lyophilized 형태로 제공됩니다. 연구용으로만 사용 가능하며, Hodgkin 림프종 등 CD30+ 세포 연구에 활용됩니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TNFRSF8 Monoclonal Antibody (OTI18D3), TrueMAB
Thermo Fisher Scientific TNFRSF8 Monoclonal Antibody (OTI18D3), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI18D3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 19-379 of human TNFRSF8 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
CD30 (Ki-1, TNF Receptor Superfamily Member 8) is a type I transmembrane glycoprotein belonging to the TNF receptor superfamily.
Originally identified on Hodgkin’s and Reed-Sternberg cells, CD30 binds to CD30L (CD153) and mediates diverse effects including proliferation, activation, differentiation, and apoptosis.
It plays a key role in Hodgkin’s disease and other CD30+ lymphomas, acts as a costimulatory molecule in thymic negative selection, and is expressed on activated T and B cells.
Soluble CD30 (sCD30) serves as a marker of Th2 immune response. CD30 interacts with TRAF2 and TRAF5 to activate NF-kappaB signaling and regulate apoptosis.
Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
CD30 expression is observed in Hodgkin’s lymphoma, Reed-Sternberg cells, Anaplastic Large Cell Lymphoma (ALCL), and embryonal carcinomas.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.