Thermo Fisher Scientific EIF3D Monoclonal Antibody (OTI1G10), TrueMAB

Applications

• Western Blot (WB): 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

eIF3D is a protein belonging to the largest subunit family of the eukaryotic translation initiation factor-3 (eIF3) complex, which consists of at least 13 different subunits.
It binds to the 40S ribosomal subunit, maintaining the 40S and 60S subunits in a dissociated state.
eIF3D plays a critical role in forming the 40S initiation complex through interaction with the ternary complex (eIF2/GTP/methionyl-tRNA) and promotes mRNA binding.
As the major RNA-binding subunit of eIF3, eIF3D associates with the p170 subunit and is ubiquitously expressed in most tissues.
It becomes phosphorylated upon DNA damage, likely by ATM or ATR.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.