Thermo Fisher Scientific Phospho-IFNAR1 (Tyr466) Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100

-

peptide-ELISA (pep-ELISA)

1:10,000

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic phosphopeptide derived from human Interferon-alpha/beta Receptor alpha chain around the phosphorylation site of Tyr446 (I-N-YP-V-F) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IFNAR1,uniProtId:P17181-1,ncbiNodeId:9606,antigenRange:446,antigenLength:557,antigenImageFileName:PA5-38502_IFNAR1_P17181-1_Rabbit.svg,antigenImageFileNamePDP:PA5-38502_IFNAR1_P17181-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2555102

Target Information

Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron,2001, Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon-& Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.