Thermo Fisher Scientific Phospho-IFNAR1 (Tyr466) Polyclonal Antibody
Phospho-IFNAR1 (Tyr466) 인산화 부위를 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 peptide-ELISA에 적합합니다. 인간 IFNAR1 단백질에서 유래한 합성 인산화 펩타이드를 면역원으로 사용하였으며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Peptide-ELISA (pep-ELISA) | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human Interferon-alpha/beta Receptor alpha chain around the phosphorylation site of Tyr446 (I-N-YP-V-F) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555102 |
Target Information
Interferons are widely used therapeutic agents because of their anti-tumor and antiviral effects, and their modulatory effects on the immune system (Biron, 2001; Kirkwood, 2002). These cytokines produce their effects by binding to the Type I Interferon Receptor (IFNAR1). Downregulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This downregulation is thought to be influenced by phosphorylation of Serine 535 and 539 in IFNAR1 (Kumar et al., 2003).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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