Thermo Fisher Scientific RRAS Monoclonal Antibody (OTI2B7), TrueMAB

Thermo Fisher Scientific RRAS Monoclonal Antibody (OTI2B7), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:500 – 1:2,000

Product Specifications

Target Information

The Ras superfamily of small GTPases includes Ras, Rho, Arf, Rab, and Ran families. Ras-regulated signaling pathways control actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration. These GTPases act as molecular switches cycling between GDP-bound inactive and GTP-bound active forms. Ras proteins are membrane-associated via prenylation. Mutations in Ras proto-oncogenes (H-Ras, N-Ras, K-Ras) are among the most frequent in human cancers, found in 20–30% of all tumors.

• K-Ras mutations: non-small-cell lung, colorectal, pancreatic carcinomas
• H-Ras mutations: bladder, kidney, thyroid carcinomas
• N-Ras mutations: melanoma, hepatocellular carcinoma, hematologic malignancies

Usage Note

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

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