Thermo Fisher Scientific RRAS Monoclonal Antibody (OTI2B7), TrueMAB
RRAS 단백질을 인식하는 Mouse IgG2b 단클론 항체로 Western blot에 최적화되어 있습니다. 인간 RRAS 전체 길이 재조합 단백질로부터 제작되었으며, 고순도 친화 크로마토그래피로 정제된 액상 형태입니다. 연구용으로 세포 신호전달 및 Ras 관련 암 연구에 활용됩니다.
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Thermo Fisher Scientific RRAS Monoclonal Antibody (OTI2B7), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution: 1:500 – 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B7 |
| Immunogen | Full length human recombinant RRAS protein produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Ras superfamily of small GTPases includes Ras, Rho, Arf, Rab, and Ran families. Ras-regulated signaling pathways control actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration. These GTPases act as molecular switches cycling between GDP-bound inactive and GTP-bound active forms. Ras proteins are membrane-associated via prenylation. Mutations in Ras proto-oncogenes (H-Ras, N-Ras, K-Ras) are among the most frequent in human cancers, found in 20–30% of all tumors.
- K-Ras mutations: non-small-cell lung, colorectal, pancreatic carcinomas
- H-Ras mutations: bladder, kidney, thyroid carcinomas
- N-Ras mutations: melanoma, hepatocellular carcinoma, hematologic malignancies
Usage Note
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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