Thermo Fisher Scientific SETD2 Polyclonal Antibody
SETD2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC에 사용 가능. 인간에 반응하며, Protein A 정제 및 1 mg/mL 농도의 액상 형태. -20°C 보관, H3K36me3 형성 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.2–1 µg | View 1 publication |
| Immunohistochemistry (IHC) | 4–8 µg/mL | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human SETD2 (aa 323–372) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2605635 |
Product Specific Information
Peptide sequence:
SDEDSVRTSS SQRSHDLKFS ASIEKERDFK KSSAPLKSED LGKPSRSKTD
Sequence homology:
Cow: 79% • Dog: 86% • Horse: 86% • Human: 100% • Mouse: 83% • Rat: 85%
Target Information
Histone methyltransferase that specifically trimethylates Lys-36 of histone H3 (H3K36me3) using dimethylated Lys-36 (H3K36me2) as substrate.
Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A.
Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex.
H3K36me3 also plays an essential role in maintaining a heterochromatic state by recruiting DNA methyltransferase DNMT3A.
Enhanced in intron-containing genes, suggesting SETD2 recruitment is coupled to splicing and elongating RNA polymerase.
Required during angiogenesis and recruited to adenovirus 12 E1A gene promoters during infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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