Thermo Fisher Scientific Azurocidin Polyclonal Antibody
인간 Azurocidin 단백질에 특이적인 Rabbit Polyclonal Antibody로, IHC(P)에서 1:50~1:200 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 완충액에 보관. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Azurocidin. Recombinant protein control fragment (Product # RP-101488) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638412 |
Product Specific Information
Immunogen sequence:
FPRFVNVTVT PEDQCRPNNV CTGVLTRRGG ICNGDGGTPL VCEGLAHGVA SFSLGPCGRG PDFFT
Highest antigen sequence identity to the following orthologs:
- Mouse: 48%
- Rat: 48%
Target Information
Azurocidin, also called heparin-binding protein (HBP), is an inactive homolog of serine proteinases residing in granulocytes. Initially it was thought to act only against gram-negative bacteria, but later found to also target gram-positive bacteria and C. albicans.
It is a member of the polymorphonuclear leukocyte-derived antimicrobial protein family, including defensins, LL-37, and lysozyme.
Azurocidin plays a role in immune response activation and modulation. Its cationic domain is essential for antimicrobial activity. It is stored in azurophil and secretory granules and released early during extravasation.
Functions include chemotaxis, activation of monocytes, cytokine release, and enhanced phagocytosis, contributing to bacterial clearance.
High plasma levels of azurocidin may serve as a biomarker for identifying patients at risk of developing sepsis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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