Thermo Fisher Scientific Azurocidin Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
FPRFVNVTVT PEDQCRPNNV CTGVLTRRGG ICNGDGGTPL VCEGLAHGVA SFSLGPCGRG PDFFT

Highest antigen sequence identity to the following orthologs:

• Mouse: 48%
• Rat: 48%

Target Information

Azurocidin, also called heparin-binding protein (HBP), is an inactive homolog of serine proteinases residing in granulocytes. Initially it was thought to act only against gram-negative bacteria, but later found to also target gram-positive bacteria and C. albicans.
It is a member of the polymorphonuclear leukocyte-derived antimicrobial protein family, including defensins, LL-37, and lysozyme.

Azurocidin plays a role in immune response activation and modulation. Its cationic domain is essential for antimicrobial activity. It is stored in azurophil and secretory granules and released early during extravasation.
Functions include chemotaxis, activation of monocytes, cytokine release, and enhanced phagocytosis, contributing to bacterial clearance.

High plasma levels of azurocidin may serve as a biomarker for identifying patients at risk of developing sepsis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.