Thermo Fisher Scientific SOCS6 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

The antibody detects endogenous levels of total SOCS6 protein.

Target Information

The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally, the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box.
SOCS proteins form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each SOCS gene occurs rapidly in response to cytokines, and once produced, the various members inhibit signaling in different ways.
SOCS1 and SOCS6 interact with the insulin receptor (IR) when expressed in human hepatoma cells (HepG2) or in rat hepatoma cells overexpressing human IR. Both inhibit insulin-dependent activation of ERK1/2 and protein kinase B in vivo and IR-directed phosphorylation of IRS1 in vitro.
These results suggest that SOCS proteins may inhibit IR signaling and could mediate cytokine-induced insulin resistance, contributing to the pathogenesis of type II diabetes.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.