Thermo Fisher Scientific PALB2 Polyclonal Antibody
PALB2 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC, IP 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태. BRCA 복합체 연구 및 DNA 손상 복구 메커니즘 분석에 유용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 675 and 725 of human partner and localizer of BRCA2 (PALB2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer.
The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and, like BRCA1 and BRCA2, is a breast cancer susceptibility gene. PALB2 functions by directly binding to BRCA1, allowing the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage.
Analysis of the BRCA1–PALB2–BRCA2–RAD51 network may enable predictions of tumor responsiveness to therapeutic treatments. At least four isoforms of PALB2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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