Thermo Fisher Scientific CD2 Polyclonal Antibody, Biotin
CD2 단백질을 표적으로 하는 Biotin 결합 Rabbit Polyclonal Antibody입니다. Western blot, IHC, ELISA, IP 등 다양한 응용에 사용됩니다. 고순도 친화 크로마토그래피 정제 및 안정적인 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acid region 335–351 on human T-cell surface antigen CD2 protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD2 (LFA-2) is a monomeric surface antigen (MW range 45–58 kDa) of the human T-lymphocyte lineage, expressed on all peripheral blood T cells. It is one of the earliest T-cell markers, found on more than 95% of thymocytes and some natural killer cells, but not on B lymphocytes.
Monoclonal antibodies against CD2 inhibit rosette formation with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or closely associated with it. The CD2–CD58 interaction stabilizes adhesion between T cells and antigen-presenting or target cells.
Although CD2–CD58 binding affinity is relatively low in solution, it provides strong adhesion within the cell-cell interface. T-cell activation increases CD2 expression and lateral mobility, enhancing contact with CD58 and strengthening intercellular adhesion.
CD2 deficiency reduces intestinal inflammation and aids infection control. Diseases associated with CD2 dysfunction include penis squamous cell carcinoma and immune deficiency due to thymus absence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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