Thermo Fisher Scientific FGR Polyclonal Antibody
인간 FGR 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, Flow Cytometry, IP에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 보존제가 없는 액상 형태. 혈액세포 내 FGR 신호전달 연구용으로 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Flow Cytometry (Flow) | 1:100 |
| Immunoprecipitation (IP) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues close to the amino terminus of human FGR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10984917 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other proteins.
Target Information
FGR is a SRC-related kinase present in hematopoietic cells. It signals within multiple pathways including the integrin pathway and downstream of chemokine and cytokine receptors. The protein contains N-terminal sites for myristylation and palmitoylation, a PTK domain, and SH2 and SH3 domains which mediate protein-protein interactions with phosphotyrosine-containing and proline-rich motifs. It localizes to plasma membrane ruffles and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in overexpression of this protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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