Thermo Fisher Scientific CD33 Monoclonal Antibody (OTI2B2), TrueMAB
CD33 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot, ICC/IF, Flow cytometry에 사용 가능. 인간 시료에 반응하며, Affinity chromatography로 정제됨. PBS/BSA/glycerol 용액 형태로 -20°C 보관.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD33 Monoclonal Antibody (OTI2B2), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:4,000 | |
| Immunocytochemistry (ICC/IF) | 1:100 | |
| Flow Cytometry (Flow) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B2 |
| Immunogen | Full length human recombinant protein of human CD33 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules capable of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies. These ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface.
CD33 is expressed on cells of the myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and serves as a therapeutic target for acute myeloid leukemia. It is found on granulocyte and macrophage precursors in the bone marrow, but not on pluripotent stem cells, and is also expressed on peripheral monocytes. CD33 is useful for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias. Diseases associated with CD33 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.