Thermo Fisher Scientific Phospho-beta Catenin (Tyr489) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Beta-catenin, an adherens junction (AJ) protein, is a key component of cell-cell adhesion structures. AJs are essential for epithelial layer formation and maintenance by regulating cell growth and adhesion. Beta-catenin interacts with the cytoplasmic domain of E-cadherin, linking it to alpha-catenin and anchoring the E-cadherin complex to the actin cytoskeleton.

It also associates with complexes containing adenomatous polyposis coli protein and microtubules, participating in signaling pathways involving tyrosine kinases, phosphatases, and Wnt/Wingless. These interactions regulate morphogenesis and cellular differentiation.

Beta-catenin is expressed in various hair follicle cell types and epithelial tissues. Abnormal beta-catenin activity has been linked to pilomatrixoma, medulloblastoma, colorectal, ovarian, and other solid tumors. In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors, promoting transcription of genes such as cyclin D and c-myc, which drive cell proliferation and tumorigenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.