Thermo Fisher Scientific Phospho-beta Catenin (Tyr489) Polyclonal Antibody
Rabbit polyclonal antibody specific for phosphorylated beta-Catenin (Tyr489). Validated for WB and IHC-P. Supplied as 1 mg/mL liquid, unconjugated form. For research use only, not for diagnostic applications.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:100 |
Product Specifications
| Specification | Detail |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human Catenin-beta around the phosphorylation site of Tyr489 (L-H-YP-G-L) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2556266 |
Target Information
Beta-catenin, an adherens junction (AJ) protein, is a key component of cell-cell adhesion structures. AJs are essential for epithelial layer formation and maintenance by regulating cell growth and adhesion. Beta-catenin interacts with the cytoplasmic domain of E-cadherin, linking it to alpha-catenin and anchoring the E-cadherin complex to the actin cytoskeleton.
It also associates with complexes containing adenomatous polyposis coli protein and microtubules, participating in signaling pathways involving tyrosine kinases, phosphatases, and Wnt/Wingless. These interactions regulate morphogenesis and cellular differentiation.
Beta-catenin is expressed in various hair follicle cell types and epithelial tissues. Abnormal beta-catenin activity has been linked to pilomatrixoma, medulloblastoma, colorectal, ovarian, and other solid tumors. In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors, promoting transcription of genes such as cyclin D and c-myc, which drive cell proliferation and tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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