Thermo Fisher Scientific TRPC4 Polyclonal Antibody
TRPC4 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot 및 IHC에 적합합니다. Mouse 종에 반응하며, 합성 펩타이드를 면역원으로 사용했습니다. 동결건조 형태로 제공되며, 4°C 단기 보관 또는 -20°C 장기 보관이 권장됩니다.
- 카탈로그번호
- OST00475W-100UL
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | 1:1,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from mouse TRPC4 conjugated to blue carrier protein was used as the antigen |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: TRPC4.
Target Information
TRPC4 is a member of the canonical subfamily of transient receptor potential cation channels. It forms a non-selective, calcium-permeable cation channel activated by Gq-coupled receptors and tyrosine kinases. TRPC4 is involved in endothelial permeability, vasodilation, neurotransmitter release, and cell proliferation.
Single nucleotide polymorphisms in TRPC4 may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
The TRPC subfamily (TRPC1–7) is most closely related to the Drosophila TRP channel, the founding member of the TRP family. Diseases associated with TRPC4 include Photosensitive Epilepsy.
CaV3.3 encodes the pore-forming alpha subunit of a voltage-gated calcium channel. This T-type channel activates and inactivates more slowly than other T-type channels and may be involved in neuronal calcium signaling.
Alternate splicing results in multiple transcript variants of CaV3.3. Voltage-gated calcium channels (CaV) mediate calcium influx in excitable cells, regulating contraction, secretion, neurotransmission, and gene expression. Diseases associated with CACNA1I include Childhood Absence Epilepsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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