Thermo Fisher Scientific TRPC4 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• Specificity: TRPC4.

Target Information

TRPC4 is a member of the canonical subfamily of transient receptor potential cation channels. It forms a non-selective, calcium-permeable cation channel activated by Gq-coupled receptors and tyrosine kinases. TRPC4 is involved in endothelial permeability, vasodilation, neurotransmitter release, and cell proliferation.
Single nucleotide polymorphisms in TRPC4 may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed.

The TRPC subfamily (TRPC1–7) is most closely related to the Drosophila TRP channel, the founding member of the TRP family. Diseases associated with TRPC4 include Photosensitive Epilepsy.

CaV3.3 encodes the pore-forming alpha subunit of a voltage-gated calcium channel. This T-type channel activates and inactivates more slowly than other T-type channels and may be involved in neuronal calcium signaling.
Alternate splicing results in multiple transcript variants of CaV3.3. Voltage-gated calcium channels (CaV) mediate calcium influx in excitable cells, regulating contraction, secretion, neurotransmission, and gene expression. Diseases associated with CACNA1I include Childhood Absence Epilepsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.