Thermo Fisher Scientific WIBG Polyclonal Antibody
Rabbit polyclonal antibody against human WIBG protein. Validated for ICC/IF applications. Antigen affinity purified and supplied in PBS with glycerol. Suitable for research use in studying exon junction complex regulation and mRNA processing.
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Applications
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human WIBG. Recombinant protein control fragment (Product #RP-97825) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664582 |
Product Specific Information
Immunogen sequence:
KEKRRQQQEKG EAEALSRTLD KVSLEETAQL PSAPQGSRAA PTAASDQPDS AATTEKAKKI KNLK
Highest antigen sequence identity to the following orthologs:
- Mouse: 82%
- Rat: 78%
Target Information
WIBG is a key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of exon-exon junctions on mRNAs. It serves as a positional landmark for intron-exon structure and directs post-transcriptional processes such as mRNA export, nonsense-mediated mRNA decay (NMD), and translation. WIBG acts as an EJC disassembly factor, allowing translation-dependent removal and recycling of EJC. Its association with the 40S ribosomal subunit likely prevents translation-independent disassembly, restricting activity to translated mRNAs. WIBG interferes with NMD and enhances translation of spliced mRNAs, possibly by antagonizing EJC functions. RNA-binding has been observed in some studies (PubMed:14968132) but not others (PubMed:19410547), and its in vivo relevance remains unclear. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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