Thermo Fisher Scientific KCNK18 Polyclonal Antibody
Rabbit에서 생산된 KCNK18 폴리클로날 항체로 인간 KCNK18 단백질을 인식합니다. 액상 형태, 0.1 mg/mL 농도이며 연구용으로 사용됩니다. TRESK 채널 연구 및 면역 관련 기능 분석에 적합합니다.
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- PA560810
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- pk
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Thermo Fisher Scientific KCNK18 Polyclonal Antibody
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human KCNK18 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2642944 |
Product Specific Information
- Immunogen sequence: ILSTSYNRFR KFPFFTRPLL SKWCPKSLFK KKPDPKPADE AVPQIIISAE ELPGPKLGTC PSR
- Highest antigen sequence identity to the following orthologs:
- Mouse: 37%
- Rat: 48%
Target Information
TRESK (TWIK-related spinal cord K⁺ channel) is a two-pore domain K⁺ channel that induces outward rectification and functions as a background K⁺ channel. It is abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes.
TRESK is activated by increased cytoplasmic calcium concentration through calcineurin, as well as by acetylcholine and histamine.
It has been suggested that TRESK is linked to acute and chronic pain by activation of calcineurin. Other studies indicate that TRESK may play a role in the regulation of T-cell function and could be an excellent target to treat T-cell originated immune dysfunction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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