Thermo Fisher Scientific KCNK18 Polyclonal Antibody

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human KCNK18 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:KCNK18,uniProtId:Q7Z418-1,ncbiNodeId:9606,antigenRange:158-220,antigenLength:384,antigenImageFileName:PA5-60810_KCNK18_Q7Z418-1_Rabbit.svg,antigenImageFileNamePDP:PA5-60810_KCNK18_Q7Z418-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2642944

Product Specific Information

Immunogen sequence: ILSTSYNRFR KFPFFTRPLL SKWCPKSLFK KKPDPKPADE AVPQIIISAE ELPGPKLGTC PSR

Highest antigen sequence identity to the following orthologs: Mouse - 37%, Rat - 48%.

Target Information

TRESK (TWIK-related spinal cord K+ channel) is a two-pore domain K+ channel that induces outward rectification and functions as a background K+ channel that is abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes. TRESK is activated by increased cytoplasmic calcium concentration through calcineurin as well as by acetylcholine and histamine. It has been suggested that TRESK is linked to acute and chronic pain by activation of calcineurin. Other studies indicate that TRESK may play a role in the regulation of T-cell function and could be an excellent target to treat T-cell originated immune dysfunction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.