Thermo Fisher Scientific Periostin Monoclonal Antibody (OTI1A1), TrueMAB
인간 Periostin 단백질을 인식하는 Mouse IgM 단일클론 항체로, WB 및 ICC/IF에 사용 가능. 액상 형태이며 1 mg/mL 농도로 제공. PBS, BSA, glycerol 포함 저장용액. 골아세포 관련 단백질 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgM |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–230 of human periostin produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide-linked protein originally isolated as an osteoblast-specific factor. It is a secreted protein that binds heparin and functions as a ligand for α(V)β(3) and α(V)β(5) integrins.
In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading, and attachment.
Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus, and breast tissues, but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer.
Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1 (TGF-β1).
Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain showing homology with the insect protein fasciclin, and a C-terminal domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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