Thermo Fisher Scientific Cytokeratin Pan Antibody Cocktail
광범위한 케라틴 인식 항체 칵테일로 다양한 상피성 종양 구분에 활용 가능. Western blot, IHC, ICC 등 다중 응용 적합. 인간 및 마우스 반응성. 단백질 A/G 정제, 액상 형태로 4°C 보관.
- 카탈로그번호
- MA513203
- 카테고리
- Antibodies
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 | View 5 publications |
| Immunohistochemistry (IHC) | – | View 15 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL | – |
| Immunohistochemistry (Frozen) (IHC (F)) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:20–1:200 | View 13 publications |
| Flow Cytometry (Flow) | – | View 1 publication |
| Miscellaneous PubMed (Misc) | – | View 1 publication |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Fish, Guinea pig, Human, Mouse, Pig |
| Host / Isotype | Mouse / IgG, kappa |
| Class | Cocktail |
| Type | Antibody |
| Clone | PAN-CK |
| Immunogen | Human epidermal keratins |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10942225 |
Product Specific Information
This antibody is a broad-spectrum pan-keratin monoclonal antibody cocktail which recognizes keratin 4, 5, 6, 7, 8, 10, 13, 14, 18, and 19.
It can differentiate between epithelial and non-epithelial tumors.
For staining of formalin-fixed tissue, digest sections with trypsin at 1 mg/mL in PBS for 10 min at 37°C, or Protease XXV at 1 mg/mL in PBS for 5 min at 37°C.
Target Information
Cytokeratin pan belongs to a subfamily of intermediate filament proteins characterized by remarkable biochemical diversity.
They are represented in human epithelial tissues by at least 20 different polypeptides, ranging from 40–68 kDa and with an isoelectric pH between 4.9–7.8.
Individual human cytokeratins are numbered 1–20. Expression patterns vary by epithelial type, maturation stage, and differentiation degree.
Cytokeratin subtype expression is widely used for distinguishing different epithelial malignancies.
These antibodies assist in tumor differential diagnosis via immunohistochemistry, cytopathology, and flow cytometry.
Keratin composition varies with cell type, growth environment, and disease state, serving as valuable markers in cancer research and tumor diagnostics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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