Thermo Fisher Scientific Human SPTLC2 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 15 amino acids near the carboxy terminus of human SPT2.
PEP-1256 can be used as a blocking peptide with polyclonal antibody PA5-21142.

Target Information

Serine palmitoyltransferase (SPT), which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor.
SPT2 is the long chain base subunit 2 of mammalian serine palmitoyltransferase. SPT2 is catalytically active but requires its related protein SPT1 for stabilization and anchoring of the holoenzyme to the cytosolic face of the endoplasmic reticulum.
Mutations in the SPT2 gene can cause hereditary sensory and autonomic neuropathy type I (HSAN-I), resulting from a loss of SPT activity and accumulation of the atypical and neurotoxic sphingoid metabolite 1-deoxy-sphinganine.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.