Thermo Fisher Scientific SCN5A Polyclonal Antibody

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) [IHC (P)]: 8–10 µg/mL

Product Specifications

Product Specific Information

• This antibody is expected to recognize all reported isoforms (NP_932173.1; NP_000326.2; NP_001092874.1; NP_001092875.1).
• Tested in Peptide ELISA: antibody detection limit dilution 1:2,000.

Target Information

Scn5a is an integral membrane protein and a tetrodotoxin-resistant voltage-gated sodium channel subunit primarily found in cardiac muscle. It is responsible for the initial upstroke of the action potential in an electrocardiogram.
Defects in Scn5a are associated with Long QT Syndrome type 3 (LQT3) and Brugada Syndrome 1.
Alternative splicing results in multiple transcript variants encoding different isoforms.

Voltage-gated sodium channels (VGSCs) mediate cell membrane depolarization and electrical signal conduction in nerves and muscles. Expression of Scn5a is also detected in lymphocytes, glia, and fibroblasts.
Scn5a mediates voltage-dependent sodium ion permeability, forming sodium-selective channels that open or close in response to membrane potential changes. Channel inactivation is regulated by intracellular calcium levels.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.