ELK Biotechnology Cot (phospho Ser400) rabbit pAb
MAP3K8의 Ser400 인산화 부위를 인식하는 폴리클로날 항체로, IHC, IF, ELISA에 사용 가능. 세포질 내 단백질 인식에 적합하며, 인산화 신호전달 연구에 유용. 사람, 마우스, 랫트 반응성. -20°C에서 1년 보관 가능.
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제품명
Cot (phospho Ser400) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | MAP3K8; COT; ESTF; Mitogen-activated protein kinase kinase kinase 8; Cancer Osaka thyroid oncogene; Proto-oncogene c-Cot; Serine/threonine-protein kinase cot; Tumor progression locus 2; TPL-2 |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human MAP3K8 around the phosphorylation site of Ser400 (AA range: 366–415) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 1326 |
| Human Swiss-Prot No. | P41279 |
| Cellular Localization | Cytoplasm |
| Species Reactivity | Human, Mouse, Rat |
Background
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. It activates IkappaB kinases, inducing nuclear NF-kappaB production, and promotes TNF-alpha and IL-2 production during T lymphocyte activation. This gene may utilize a downstream in-frame translation start codon to produce a shorter isoform with weaker transforming activity. Alternative splicing results in multiple transcript variants encoding the same protein.
[Provided by RefSeq, Sep 2011]
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