ELK Biotechnology COL4A3 rabbit pAb
COL4A3 단백질을 인식하는 토끼 폴리클로날 항체로, IHC, IF, ELISA에 사용 가능. 인간, 랫, 마우스 시료에 반응. 합성 펩타이드(AA 801-850)로부터 면역화. 세포외 기질 및 기저막 단백질 연구에 적합. -20°C에서 1년 보관.
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제품명
COL4A3 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | COL4A3; Collagen alpha-3(IV) chain; Goodpasture antigen |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Collagen IV alpha3 (AA range: 801–850) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 1285 |
| Human Swiss-Prot No. | Q01955 |
| Cellular Localization | Secreted, extracellular space, extracellular matrix, basement membrane. Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL). |
| Species Reactivity | Human; Rat; Mouse |
Background
Type IV collagen is the major structural component of basement membranes and is a multimeric protein composed of three alpha subunits. These subunits are encoded by six different genes (α1–α6), each forming a triple helix structure with two others to create type IV collagen.
The COL4A3 gene encodes the alpha 3 chain. In Goodpasture syndrome, autoantibodies bind to collagen molecules in the basement membranes of alveoli and glomeruli, primarily targeting epitopes in the non-collagenous C-terminal domain.
A specific kinase phosphorylates amino acids in this region, and its expression increases during pathogenesis. Mutations in COL4A3 are also associated with an autosomal recessive form of Alport syndrome, with mutations located within exons encoding the C-terminal region.
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