
ELK Biotechnology A Cyclase VIII rabbit pAb
ADCY8 단백질을 인식하는 토끼 폴리클로날 항체로 IHC, IF, ELISA에 사용 가능. 인간, 마우스, 랫트 시료에 반응. 세포막 및 시냅스 부위에 주로 존재하는 단백질 검출에 적합. -20°C에서 1년 보관 가능.
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제품명
A Cyclase VIII rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ADCY8; Adenylate cyclase type 8; ATP pyrophosphate-lyase 8; Adenylate cyclase type VIII; Adenylyl cyclase 8; AC8; Ca(2+)/calmodulin-activated adenylyl cyclase |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human ADCY8 (AA range: 591–640) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 114 |
| Human Swiss-Prot No | P40145 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Cell membrane; Multi-pass membrane protein; Basolateral cell membrane; Apical cell membrane; Cell junction (synapse); Cell projection (dendrite, axon); Presynaptic cell membrane; Postsynaptic density; Membrane raft; Clathrin-coated vesicle membrane; Caveola.
Monomeric N-glycosylated species localize in membrane raft; unglycosylated forms are enriched in clathrin-coated pits and vesicles. Dimers are localized outside membrane rafts. Membrane raft localization and integrity are indispensable for CCE-stimulated adenylate cyclase activity.
배경 (Background)
Adenylate cyclase is a membrane-bound enzyme that catalyzes the formation of cyclic AMP from ATP. Its enzymatic activity is regulated by several hormones, and signal transduction involves G proteins (Gs and Gi) that modulate the catalytic subunit of adenylyl cyclase.
[Provided by RefSeq, Jul 2008]
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