ELK Biotechnology Chk2 (phospho Thr383) rabbit pAb
Chk2 (phospho Thr383) rabbit pAb는 DNA 손상 반응 연구용 항체로, 인산화된 Thr383 부위를 인식합니다. WB, IF, ELISA에 사용 가능하며 인간, 마우스, 랫드, 원숭이에 반응합니다. Polyclonal IgG로 -20°C에서 1년 보관 가능합니다.
- 판매단위
- pk
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제품명
Chk2 (phospho Thr383) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CHEK2; CDS1; CHK2; RAD53; Serine/threonine-protein kinase Chk2; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2 |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Chk2 around the phosphorylation site of Thr383. AA range: 356-405 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kD |
| GeneID (Human) | 11200 |
| Human Swiss-Prot No | O96017 |
| Cellular Localization | [Isoform 2]: Nucleus. Isoform 10 is present throughout the cell. [Isoform 4]: Nucleus. [Isoform 7]: Nucleus. [Isoform 9]: Nucleus. [Isoform 12]: Nucleus. Nucleus, PML body. Nucleus, nucleoplasm. Recruited into PML bodies together with TP53. |
| Species Reactivity | Human; Mouse; Rat; Monkey |
Background
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein inhibits CDC25C phosphatase, preventing entry into mitosis, and stabilizes the tumor suppressor protein p53, leading to cell cycle arrest in G1. Additionally, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype associated with inherited mutations.
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