
ELK Biotechnology A Cyclase V/VI rabbit pAb
Adenylyl cyclase V/VI 단백질을 인식하는 토끼 다클론 항체로, IHC, IF, ELISA에 적합합니다. 인간, 마우스, 랫트에 반응하며 세포막 및 섬모에 위치한 단백질 검출에 유용합니다. -20°C에서 1년 보관 가능합니다.
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제품명
A Cyclase V/VI rabbit pAb
제품 개요
Adenylyl cyclase V/VI 단백질을 인식하는 토끼 다클론 항체입니다. 이 단백질은 세포 내 cAMP 합성에 관여하며, G 단백질 연결 수용체 신호전달 경로의 중요한 효과기 역할을 합니다.
제품 사양
| 항목 | 내용 |
|---|---|
| Product name | A Cyclase V/VI rabbit pAb |
| Alternative Names | ADCY6; KIAA0422; Adenylate cyclase type 6; ATP pyrophosphate-lyase 6; Adenylate cyclase type VI; Adenylyl cyclase 6; Ca(2+)-inhibitable adenylyl cyclase; ADCY5; Adenylate cyclase type 5; ATP pyrophosphate-lyase 5; Adenylate cyclase type V |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human ADCY5/6 (AA range: 931–980) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 112 / 111 |
| Human Swiss-Prot No | O43306 / O95622 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein; Cell projection (cilium, stereocilium) |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the adenylyl cyclase family of proteins, which are required for the synthesis of cyclic AMP. All members of this family have an intracellular N-terminus, a tandem repeat of six transmembrane domains separated by a cytoplasmic loop, and a C-terminal cytoplasmic domain. The two cytoplasmic regions bind ATP and form the catalytic core of the protein. Adenylyl cyclases are important effectors of transmembrane signaling pathways and are regulated by the activity of G protein-coupled receptor signaling. This protein belongs to a small subclass of adenylyl cyclase proteins that are functionally related and are inhibited by protein kinase A, calcium ions, and nitric oxide. A mutation in this gene is associated with arthrogryposis multiplex congenita. [provided by RefSeq, May 2015]
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