ELK Biotechnology p27 (phospho Ser178) rabbit pAb

ELK Biotechnology p27 (phospho Ser178) rabbit pAb

제품 개요

p27 (phospho Ser178) rabbit polyclonal antibody는 인간 p27 Kip1 단백질의 Ser178 인산화 부위를 인식하도록 제작된 항체입니다. 세포주기 조절 및 단백질 위치 변화 연구에 활용됩니다.

제품 정보

세포 내 위치 (Cellular Localization)

• Nucleus, Cytoplasm, Endosome
• Nuclear and cytoplasmic in quiescent cells
• AKT- or RSK-mediated phosphorylation on Thr-198 enables cytoplasmic translocation and promotes cell cycle progression
• UHMK1 phosphorylation on Ser-10 also induces cytoplasmic translocation and progression
• Phosphorylation on Ser-10 facilitates nuclear export
• Phosphorylation of Tyr-88 and Tyr-89 triggers nuclear import
• Colocalizes at the endosome with SNX6, leading to lysosomal degradation (By similarity)

배경 (Background)

This gene encodes a cyclin-dependent kinase inhibitor that shares limited similarity with CDKN1A/p21. The protein binds to and prevents activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, controlling cell cycle progression at G1. Its degradation, triggered by CDK-dependent phosphorylation and ubiquitination by SCF complexes, is required for transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [RefSeq, Apr 2014]