ELK Biotechnology CD3EAP rabbit pAb

CD3EAP rabbit pAb

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세포 내 위치

Nucleus, nucleolus, chromosome.
Found at the fibrillar centers of the nucleolus in interphase and during cell division, it is localized to the nucleolus organizer regions of the chromosomes.

Background

• Caution: It is not known whether the so-called human ASE1 and human CAST proteins represent two sides of a single gene product with sharply different functional characteristics.
• Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation. Isoform 2 has been described as a component of preformed T-cell receptor (TCR) complex.
• Miscellaneous: It is in an antisense orientation to and overlaps the gene of the DNA repair enzyme ERCC1. This gene overlap is conserved in mouse suggesting an important biologic function.
• PTM: Isoform 1 is phosphorylated on tyrosine residues in initiation-competent Pol I-beta complexes but not in Pol I-alpha complexes. Isoform 2 undergoes tyrosine phosphorylation upon T-cell receptor (TCR) stimulation. Phosphorylated upon DNA damage, probably by ATM or ATR.
• Similarity: Belongs to the eukaryotic RPA34 RNA polymerase subunit family.
• Subunit: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits. Interacts with TAF1A thereby associates with the SL1 complex. Interacts with UBTF. Interacts with POLR1E/PRAF1 through its N-terminal region. Isoform 2 interacts with CD3E.