ELK Biotechnology TIP60 (phospho Ser90) rabbit pAb
TIP60 (phospho Ser90) rabbit pAb는 인간, 마우스, 랫트 시료에 반응하며, IHC, IF, ELISA 등에 사용 가능합니다. 세포 내 인산화된 Ser90 부위 인식. 핵, 염색체, 세포질 등 다양한 세포 위치에서 발현 검출에 적합. DNA 수리 및 세포 신호전달 연구에 활용.
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제품명
TIP60 (phospho Ser90) rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | KAT5; HTATIP; TIP60; Histone acetyltransferase KAT5; 60 kDa Tat-interactive protein; Tip60; Histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; Lysine acetyltransferase 5; cPLA(2)-interacting protein |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Antiserum produced against synthesized peptide derived from human Tip60 around phosphorylation site of Ser90 (AA range: 56–105) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 10524 |
| Human Swiss-Prot No | Q92993 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Nucleus, Chromosome, Cytoplasm, Chromosome (centromere, kinetochore), Cytoskeleton (spindle pole), Nucleus (nucleolus), Cytoplasm (perinuclear region).
Upon stimulation with EDN1, exported from the nucleus to the perinuclear region.
UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies (PubMed:11262386).
Transiently localizes to kinetochores in early mitosis (PubMed:26829474).
Localizes to spindle poles during metaphase (PubMed:34608293).
Also found in cytoplasm and nucleus of round spermatids (By similarity).
배경
The protein encoded by this gene belongs to the MYST family of histone acetyltransferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein.
HATs regulate chromatin remodeling, transcription, and other nuclear processes by acetylating histone and non-histone proteins.
This protein plays roles in DNA repair and apoptosis and is involved in signal transduction.
Alternative splicing results in multiple transcript variants. (RefSeq, Jul 2008)
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