ELK Biotechnology C/EBP α (phospho Thr230) rabbit pAb
C/EBP α (phospho Thr230) rabbit polyclonal antibody로, 인산화된 Thr230 부위를 인식합니다. WB와 ELISA에 적합하며, 사람, 생쥐, 쥐 시료에서 반응합니다. 핵 내 전사인자 검출에 유용하며, 급성 골수성 백혈병 관련 연구에 활용 가능합니다.
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제품명
C/EBP α (phospho Thr230) rabbit pAb
제품 개요
C/EBP α는 CCAAT 모티프를 인식하는 전사인자로, 세포주기 조절 및 체중 항상성 유지에 관여합니다. 본 항체는 Thr230 인산화 부위를 특이적으로 인식하는 rabbit polyclonal antibody입니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | C/EBP α (phospho Thr230) rabbit pAb |
| Alternative Names | CEBPA; CCAAT/enhancer-binding protein alpha; C/EBP alpha |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human C/EBP α (phospho Thr230) |
| Storage | -20°C, 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 42 kDa, also have 30 kDa isoform |
| GeneID (Human) | 1050 |
| Human Swiss-Prot No | P49715 |
| Cellular Localization | Nucleus; [Isoform 4]: Nucleus, nucleolus |
| Species Reactivity | Human; Mouse; Rat |
Background
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate expression of genes involved in cell cycle regulation and body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]
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