ELK Biotechnology p27 (phospho Thr198) rabbit pAb

제품명

p27 (phospho Thr198) rabbit pAb

공급업체

ELK Biotechnology

제품 개요

본 항체는 인간 p27 Kip1 단백질의 Thr198 인산화 부위를 기반으로 제작된 폴리클로날 항체입니다. 세포 주기 조절 관련 연구 및 인산화 단백질 분석에 활용됩니다.

제품 상세 정보

세포 내 위치

Nucleus, Cytoplasm, Endosome.
In quiescent cells, localized in both nuclear and cytoplasmic regions.
AKT- or RSK-mediated phosphorylation on Thr-198 promotes cytoplasmic translocation and cell cycle progression.
Phosphorylation on Ser-10 facilitates nuclear export; Tyr-88 and Tyr-89 phosphorylation induces nuclear translocation.
Colocalizes at endosome with SNX6, leading to lysosomal degradation (By similarity).

Background

This gene encodes a cyclin-dependent kinase inhibitor that shares limited similarity with CDKN1A/p21.
The protein binds and inhibits cyclin E-CDK2 or cyclin D-CDK4 complexes, controlling cell cycle progression at G1.
Degradation of this protein, triggered by CDK-dependent phosphorylation and ubiquitination by SCF complexes, is necessary for transition from quiescence to proliferation.
Mutations are associated with multiple endocrine neoplasia type IV (MEN4).
[provided by RefSeq, Apr 2014]