ELK Biotechnology SAP 49 rabbit pAb
SF3B4 단백질을 인식하는 rabbit polyclonal antibody로, WB, IHC, IF, ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. 핵 내 단백질 검출에 적합하며, 고특이적 RNA 결합 단백질 연구에 활용 가능.
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제품명
SAP 49 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | SF3B4; SAP49; Splicing factor 3B subunit 4; Pre-mRNA-splicing factor SF3b 49 kDa subunit; SF3b50; Spliceosome-associated protein 49; SAP 49 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SF3B4 (AA range: 61–110) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 55 kDa |
| Gene ID (Human) | 10262 |
| Human Swiss-Prot No. | Q15427 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It may also be involved in the assembly of the B, C, and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA.
[provided by RefSeq, Jul 2008]
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