ELK Biotechnology Cdk5 rabbit pAb
Cyclin-dependent kinase 5(Cdk5)를 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 세포 내 신경 관련 단백질 연구에 활용됩니다. -20°C에서 1년 보관 가능합니다.
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제품명
Cdk5 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CDK5; CDKN5; Cyclin-dependent kinase 5; Cell division protein kinase 5; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CDK5. AA range: 1-50 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 33 kD |
| Gene ID (Human) | 1020 |
| Human Swiss-Prot No. | Q00535 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm, Nucleus, Cell membrane (Peripheral membrane protein), Perikaryon, Lamellipodium, Growth cone, Synapse (postsynaptic density). Under neurotoxic stress, CDK5R (p35) is cleaved by calpain to generate CDK5R1 (p25), leading to mislocalization and hyperactivation of CDK5. Colocalizes with CTNND2 and CTNNB1 in neuronal cells. |
Background
Cyclin-dependent kinase 5 (CDK5) is a proline-directed serine/threonine kinase belonging to the cyclin-dependent kinase family. Unlike other CDKs, CDK5 does not directly regulate the cell cycle but plays roles in neuronal functions such as synaptic plasticity and neuronal migration. It phosphorylates proteins involved in cytoskeletal organization, endocytosis, exocytosis, and apoptosis. Mutations leading to loss of CDK5 expression are associated with autosomal recessive lissencephaly-7. Alternative splicing produces multiple transcript variants. (RefSeq, May 2015)
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