ELK Biotechnology ACK rabbit pAb
ACK1(TNK2) 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간 및 생쥐 시료에 반응. 세포막, 핵, 엔도솜 등 다양한 세포 구획에서 발현 확인. -20°C에서 1년 보관 가능.
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제품명
ACK rabbit pAb
제품 개요
ELK Biotechnology의 ACK rabbit pAb는 인간 ACK1(TNK2) 단백질을 인식하는 토끼 폴리클로날 항체로, 다양한 응용 분야에서 사용 가능합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | TNK2; ACK1; Activated CDC42 kinase 1; ACK-1; Tyrosine kinase non-receptor protein 2 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human ACK1 (AA range: 250–299) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 115 kDa |
| GeneID (Human) | 10188 |
| Human Swiss-Prot No | Q07912 |
| Species Reactivity | Human; Mouse |
| Cellular Localization | Cell membrane, nucleus, endosome, adherens junction, cytoplasmic vesicle membrane (peripheral membrane protein), clathrin-coated vesicle, clathrin-coated pit, cytoplasm (perinuclear region, cytosol). Tyr-284 phosphorylated form found in membrane and nucleus. Co-localizes with EGFR on endosomes and with CTPS1 in filamentous cytosolic structures. Nuclear translocation is CDC42-dependent. |
Background
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This interaction involves a unique 47 amino acid sequence C-terminal to an SH3 domain. The protein may regulate the active GTP-bound form of Cdc42Hs and participate in tyrosine phosphorylation signal transduction. Several alternatively spliced transcript variants have been identified, with two full-length variants determined. (RefSeq, Jul 2008)
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