ELK Biotechnology ACK (phospho Tyr284) rabbit pAb
인간 ACK1의 인산화 Tyr284 부위를 인식하는 토끼 다클론 항체로, WB, IHC, IF, ELISA에 사용 가능. 세포막 및 핵에서 발현되는 단백질 검출에 적합하며, 고감도와 특이성을 제공. -20°C에서 1년 보관 가능.
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제품명
ACK (phospho Tyr284) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | TNK2; ACK1; Activated CDC42 kinase 1; ACK-1; Tyrosine kinase non-receptor protein 2 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human ACK1 around the phosphorylation site of Tyr284 (AA range: 250–299) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 120 kDa |
| Gene ID (Human) | 10188 |
| Human Swiss-Prot No. | Q07912 |
| Species Reactivity | Human; Mouse |
세포 내 위치
Cell membrane, nucleus, endosome, adherens junction, cytoplasmic vesicle membrane (peripheral membrane protein, cytoplasmic side), clathrin-coated vesicle, clathrin-coated pit, cytoplasm (perinuclear region, cytosol).
The Tyr-284 phosphorylated form is found both in the membrane and nucleus (By similarity).
Co-localizes with EGFR on endosomes (PubMed:20333297).
Nuclear translocation is CDC42-dependent (By similarity).
Detected in long filamentous cytosolic structures co-localizing with CTPS1 (By similarity).
Background
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GAP-stimulated GTPase activity of Cdc42Hs. This interaction is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may regulate the maintenance of the GTP-bound active form of Cdc42Hs and is linked to a tyrosine phosphorylation signal transduction pathway.
Several alternatively spliced transcript variants have been identified, though only two full-length variants have been characterized.
[Provided by RefSeq, Jul 2008]
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