ELK Biotechnology OB-cadherin rabbit pAb
OB-cadherin rabbit polyclonal antibody로 인간 및 생쥐 시료에 반응. WB와 ELISA에 적합하며, 세포막 단백질 CDH11 검출에 사용. 골아세포 분화 관련 연구 및 세포 접착 기전 분석에 유용.
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OB-cadherin rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CDH11; Cadherin-11; OSF-4; Osteoblast cadherin; OB-cadherin |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CDH11 (AA range: 421-470) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 85 kD |
| GeneID (Human) | 1009 |
| Human Swiss-Prot No | P55287 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Species Reactivity | Human; Mouse |
Background
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008]
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