ELK Biotechnology Bim (phospho Ser59) rabbit pAb
Bim 단백질의 Ser59 인산화 부위를 인식하는 토끼 폴리클로날 항체로, IHC, IF, ELISA에 사용 가능. 인간, 마우스, 랫트에 반응하며 세포 내막계 및 미토콘드리아에 위치. 세포사멸 연구에 유용.
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제품명
Bim (phospho Ser59) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | BCL2L11; BIM; Bcl-2-like protein 11; Bcl2-L-11; Bcl2-interacting mediator of cell death |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human BIM around the phosphorylation site of Ser59 (AA range: 31–80). |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 10018 |
| Human Swiss-Prot No. | O43521 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Endomembrane system; Peripheral membrane protein associated with intracytoplasmic membranes. Isoforms: - BimEL: Mitochondrion, translocates from microtubules to mitochondria on loss of cell adherence. - BimL: Mitochondrion. - BimS: Mitochondrion. - Bim-α1: Mitochondrion. |
Background
The protein encoded by this gene belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in various cellular activities. The encoded protein contains a Bcl-2 homology domain 3 (BH3) and functions as an apoptotic activator. Its expression can be induced by nerve growth factor (NGF) and the forkhead transcription factor FKHR-L1, indicating a role in neuronal and lymphocyte apoptosis. Transgenic mouse studies suggest it functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants have been identified (RefSeq, Jun 2013).
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