ELK Biotechnology EMAP II rabbit pAb
EMAP II rabbit pAb는 인간, 랫트, 마우스에 반응하는 폴리클로날 항체로, Western blot 및 ELISA에 적합합니다. AIMP1 내부 영역 유래 펩타이드로 면역화되었으며, 세포 내 및 분비 경로 단백질 검출에 활용됩니다. 농도 1 mg/ml, 저장 -20°C.
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EMAP II rabbit pAb
주요 정보
| 항목 | 내용 |
|---|---|
| Product name | EMAP II rabbit pAb |
| Alternative Names | AIMP1; EMAP2; SCYE1; Aminoacyl tRNA synthase complex-interacting multifunctional protein 1; Multisynthase complex auxiliary component p43 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from the internal region of human AIMP1 (AA range: 91-140) |
| Species Reactivity | Human; Rat; Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 34 kD |
| GeneID (Human) | 9255 |
| Human Swiss-Prot No | Q12904 |
| Cellular Localization | Nucleus; Cytoplasm (cytosol); Secreted; Endoplasmic reticulum; Golgi apparatus; Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Secreted in response to hypoxia (PubMed:10850427). Also secreted in response to both apoptotic and necrotic cell death. |
| Storage | -20°C / 1 year |
| Host | Rabbit |
Background
The protein encoded by this gene is a cytokine specifically induced by apoptosis, involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit associated with the multi-tRNA synthetase complex and modulates aminoacylation activity of tRNA synthetase in normal cells. It also stimulates inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene, and a pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]
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