ELK Biotechnology CD298 rabbit pAb
CD298(ATP1B3) 단백질을 인식하는 토끼 폴리클로날 항체로, WB와 ELISA에 적합합니다. 인간, 쥐, 생쥐 시료에 반응하며, 세포막 단백질 연구에 활용됩니다. 고순도 IgG 형태로 -20°C에서 1년 보관 가능합니다.
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제품명
CD298 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ATP1B3; Sodium/potassium-transporting ATPase subunit beta-3; Sodium/potassium-dependent ATPase subunit beta-3; ATPB-3; CD298 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human ATP1B3 (AA range: 222–271) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 36 kDa |
| Gene ID (Human) | 483 |
| Human Swiss-Prot No. | P54709 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Apical cell membrane; Single-pass type II membrane protein; Basolateral cell membrane; Melanosome (identified by mass spectrometry in melanosome fractions from stage I to stage IV) |
Background
The protein encoded by this gene belongs to the family of Na⁺/K⁺ and H⁺/K⁺ ATPase beta chain proteins, specifically the Na⁺/K⁺-ATPase subfamily. Na⁺/K⁺-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of sodium and potassium ions across the plasma membrane. These gradients are essential for osmoregulation, sodium-coupled transport of various molecules, and electrical excitability of nerve and muscle cells. The enzyme is composed of two subunits: a large catalytic alpha subunit and a smaller glycoprotein beta subunit. The beta subunit regulates the number of sodium pumps transported to the plasma membrane through alpha/beta heterodimer assembly. The glycoprotein subunit of Na⁺/K⁺-ATPase is encoded by multiple genes, and this gene encodes the beta-3 subunit.
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