원본
ELK Biotechnology CD33 rabbit pAb
상품 한눈에 보기
CD33 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot과 ELISA에 적합합니다. 인간, 쥐, 마우스 시료에 반응하며, 세포막 및 퍼옥시솜 발현 단백질 분석에 유용합니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다회원가입 없이 바로 구매하세요
가입하지 않아도 비회원가로 구매하실 수 있습니다.
카탈로그 번호 · 상품 설명출고판매가담기
ELK Biotechnology ES4314-100UL CD33 rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES4314-50UL CD33 rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology CD33 rabbit pAb
제품명
CD33 rabbit pAb
제품 개요
CD33 단백질을 표적하는 토끼 폴리클로날 항체로, 세포막 단백질 분석 및 면역학적 연구에 활용됩니다. Western blot 및 ELISA에서 검증되었습니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | CD33 rabbit pAb |
| Alternative Names | CD33; SIGLEC3; Myeloid cell surface antigen CD33; Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD33 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from the internal region of human CD33 (AA range: 71–120) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 40 kD |
| Gene ID (Human) | 945 |
| Human Swiss-Prot No | P20138 |
| Cellular Localization | [Isoform CD33M]: Cell membrane; Single-pass type I membrane protein. [Isoform CD33m]: Peroxisome (does not localize to cell surfaces but accumulates in peroxisomes). |
| Species Reactivity | Human; Rat; Mouse |
Background
- Domain: Contains two cytoplasmic immunoreceptor tyrosine-based inhibitor motifs (ITIMs) involved in modulation of cellular responses. Phosphorylated ITIM motifs bind SH2 domains of SH2-containing phosphatases.
- Function: Putative adhesion molecule of myelomonocytic-derived cells mediating sialic acid-dependent binding to cells. Preferentially binds alpha-2,6-linked sialic acid. May act as an inhibitory receptor upon ligand-induced tyrosine phosphorylation, recruiting cytoplasmic phosphatases (e.g., PTPN6, PTPN11) that block signal transduction. Induces apoptosis in acute myeloid leukemia (in vitro).
- Online Information: Siglec-3
- Post-translational Modification (PTM): Phosphorylation of Tyr-340 and Tyr-358 involved in binding to PTPN6 and PTPN11.
- Similarity: Member of the immunoglobulin superfamily, SIGLEC (sialic acid-binding Ig-like lectin) family. Contains one Ig-like C2-type and one Ig-like V-type domain.
- Subunit: Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.
- Tissue Specificity: Expressed in monocytic/myeloid lineage cells.
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.