Thermo Fisher Scientific H1N1 Hemagglutinin 2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

Influenza A virus is a major public health threat. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however, it is in birds that all subtypes can be found.

These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. HA interacts with cell surface proteins containing oligosaccharides with terminal sialyl residues, binding to sialic acid-containing receptors on the cell surface and mediating viral attachment.

This attachment induces virion internalization through both clathrin-dependent and clathrin-independent pathways. HA plays a major role in host range restriction and virulence. As a Class I viral fusion protein, it mediates penetration of the virus into the cell cytoplasm by fusing the viral envelope with the endosomal membrane. Low pH in endosomes triggers conformational changes in HA2, releasing the fusion peptide and enabling membrane fusion. Several trimers are required to form a competent fusion pore.

Target: Influenza A Virus (strain swl A/California/04/2009 H1N1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.