Thermo Fisher Scientific IkB beta Polyclonal Antibody
Thermo Fisher Scientific의 IkB beta Polyclonal Antibody는 인간 IkBβ 단백질의 C-말단 합성 펩타이드에 특이적으로 결합하는 항체입니다. Western blot과 IHC에 사용 가능하며, Protein A 정제된 고순도 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 5 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | 5 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal of human NFKBIB (aa 282–331) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2607738 |
Product Specific Information
Peptide sequence:
MLRPNPILAR LLRAHGAPEP EGEDEKSGPC SSSSDSDSGD EGDEYDDIVV
Sequence homology:
Cow: 91%
Dog: 83%
Guinea Pig: 92%
Horse: 92%
Human: 100%
Mouse: 85%
Rabbit: 77%
Rat: 92%
Target Information
The NF-κB/Rel transcription factors are present in the cytosol in an inactive state, complexed with inhibitory IkB proteins. Activation of NF-κB commonly occurs via phosphorylation-induced, proteasome-mediated degradation of IkB. The key regulatory step involves activation of the high molecular weight IkB kinase (IKK) complex, composed of IKKα, IKKβ (catalytic subunits), and IKKγ (regulatory subunit). Phosphorylation at Ser177 and Ser181 (IKKβ) or Ser176 and Ser180 (IKKα) induces conformational changes leading to kinase activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-40909_IkB_beta_Q15653-1_Rabbit.svg, PA5-40909_IkB_beta_Q15653-1_Rabbit_PDP.jpeg)
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