Thermo Fisher Scientific Periostin Recombinant Rabbit Monoclonal Antibody (HL2112)
Thermo Fisher Scientific의 Periostin Recombinant Rabbit Monoclonal Antibody (HL2112)는 인간 및 마우스 시료에 반응하며, Western blot에 적합한 고특이성 항체입니다. HEK293 세포에서 발현된 재조합 항체로, Protein A로 정제되었으며 PBS 용액에 보존됩니다. 연구용으로만 사용 가능합니다.
- 판매단위
- pk
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Applications
- Western Blot (WB): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HL2112 |
| Immunogen | Recombinant fragment of human Periostin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3093936 |
Target Information
Periostin (PN), also known as osteoblast-specific factor 2 (OSF-2), is a disulfide-linked protein originally isolated as an osteoblast-specific factor. It is a secreted protein that binds heparin and functions as a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading, and attachment.
Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus, and breast tissues, but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1 (TGF beta 1).
Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain showing homology with the insect protein fasciclin, and a C-terminal domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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