Thermo Fisher Scientific FOLH1/PSMA (Prostate Epithelial Marker) Monoclonal Antibody (FOLH1/2354)
FOLH1/PSMA 단백질을 인식하는 Mouse monoclonal antibody로, Western blot과 IHC 등 다양한 응용에 적합. 인간, 개, 고양이, 말 시료에 반응하며, 단백질 A/G 정제된 액상 형태. 전립선암 및 관련 연구용으로 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL | |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Horse, Cat, Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | FOLH1/2354 |
| Immunogen | Recombinant human FOLH1 protein fragment (around aa 232–433) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on various substrates, including folate and N-acetyl-L-aspartyl-L-glutamate, and is expressed in tissues such as the prostate, central and peripheral nervous systems, and kidney.
Mutations may lead to impaired intestinal folate absorption, resulting in low blood folate and hyperhomocysteinemia. Expression in the brain may be linked to glutamate excitotoxicity-related conditions. In the prostate, the protein is up-regulated in cancerous cells and serves as a diagnostic and prognostic marker for prostate cancer.
This gene likely originated from a chromosomal duplication event, and alternative splicing generates multiple transcript variants encoding different isoforms.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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