Thermo Fisher Scientific Human SDHD Synthetic Peptide
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카탈로그 번호 | CAS 번호 | 설명 | 상태 | 재고 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
PEP1430 | - | Thermo Fisher Scientific PEP1430 Human SDHD Synthetic Peptide 50 ug pk | 재고문의 | pk | 200,000원 | - | 220,000원 |
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Applications
Tested Dilution
Publications
Control (Ctrl)
Assay-dependent
Blocking Assay (BLOCK)
Assay-dependent
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 15 amino acid peptide near the center of human SDHD.
PEP-1430 can be used as a blocking peptide with polyclonal antibody PA5-34387.
Target Information
The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumor-suppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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