Thermo Fisher Scientific Human SDHD Synthetic Peptide
인간 SDHD 단백질의 중심부 15개 아미노산 서열로 구성된 합성 펩타이드. PA5-34387 항체의 블로킹 펩타이드로 사용 가능. 순도 높은 액상 형태로 제공되며, PBS(pH 7.2)와 0.1% BSA 포함. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to a 15 amino acid sequence near the center of human SDHD.
PEP-1430 can be used as a blocking peptide with polyclonal antibody PA5-34387.
Target Information
The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH).
Mutations in SDHD are associated with hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD may act as a tumor-suppressor gene.
In one family with a nonsense mutation (R22X) in the SDHD gene, loss of heterozygosity was found in paragangliomas, and the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished.
Furthermore, high levels of angiogenic factors EPAS1 and VEGF were observed, which may stimulate tumor growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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