Thermo Fisher Scientific PCBP1 Monoclonal Antibody (OTI10B7), TrueMAB

Applications

• Western Blot (WB): 1:2,000 dilution

Product Specifications

Target Information

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. Along with PCBP-2 and hnRNPK, it corresponds to the major cellular polydomains involved in RNA binding. This encoded protein, together with PCBP-2, also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promotes poliovirus RNA replication by binding to its 5′-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a role in formation of a sequence-specific alpha-globin mRNP complex associated with alpha-globin mRNA stability.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.