Thermo Fisher Scientific CD74 Recombinant Rabbit Monoclonal Antibody (301)

Applications

ELISA

• Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

• Specificity: Human CD74

Target Information

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB). The alpha chain gene contains five exons: exon 1 encodes the leader peptide, exons 2 and 3 encode the extracellular domains, and exon 4 encodes the transmembrane domain and cytoplasmic tail.
DRA lacks polymorphisms in the peptide-binding region and acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5. The DR beta chain contains polymorphisms specifying peptide-binding specificities, with hundreds of DRB1 alleles described. Typing for these polymorphisms is routinely performed for bone marrow and kidney transplantation.
HLA-DR is primarily expressed on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes. The human class II region includes three loci—DR, DQ, and DP—that encode major expressed products. These molecules bind intracellularly processed peptides, present them to T-helper cells, and play a critical role in initiating the immune response.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.