Thermo Fisher Scientific DRAK2 Polyclonal Antibody

Applications

• Western Blot (WB): 1–3 µg/mL

Product Specifications

Product Specific Information

• Predicted to react with canine based on sequence homology.
• Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

Target Information

STK17B (also known as DRAK2) is a member of the serine/threonine kinase family related to death-associated protein kinase that triggers apoptosis. STK17B is selectively important for T-cell survival, and inhibition of STK17B has therapeutic potential for autoimmune diseases.
T-cell survival depends on a balance of T-cell receptor and co-stimulatory signals, and deficiency of STK17B can affect autoimmune disease susceptibility without generalized immune suppression.
Protein kinases play important roles in signal transduction in response to external stimuli. Several kinases, including DRAK1 and DRAK2 (Death Receptor Associated Kinases), are involved in apoptotic processes. Overexpression of these kinases induces apoptosis, suggesting the C-terminal domain of DRAKs is important for apoptosis induction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.