Thermo Fisher Scientific DRAK2 Polyclonal Antibody
DRAK2(STK17B) 단백질을 인식하는 Goat Polyclonal 항체로, Western blot에 최적화되어 있습니다. Human에 반응하며, Peptide ELISA로 검증되었습니다. 액상형 제품으로 0.5 mg/mL 농도이며, -20°C 보관 권장됩니다.
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Applications
- Western Blot (WB): 1–3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (HSVRSSEDKTSK) corresponding to the internal amino acids of STK17B (aa 316–328) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_10977901 |
Product Specific Information
- Predicted to react with canine based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
STK17B (also known as DRAK2) is a member of the serine/threonine kinase family related to death-associated protein kinase that triggers apoptosis. STK17B is selectively important for T-cell survival, and inhibition of STK17B has therapeutic potential for autoimmune diseases.
T-cell survival depends on a balance of T-cell receptor and co-stimulatory signals, and deficiency of STK17B can affect autoimmune disease susceptibility without generalized immune suppression.
Protein kinases play important roles in signal transduction in response to external stimuli. Several kinases, including DRAK1 and DRAK2 (Death Receptor Associated Kinases), are involved in apoptotic processes. Overexpression of these kinases induces apoptosis, suggesting the C-terminal domain of DRAKs is important for apoptosis induction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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