Thermo Fisher Scientific LEPR Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

The leptin (OB-R) receptor is a member of the cytokine receptor superfamily, playing a crucial role in mammalian body weight homeostasis and energy balance. Activation of OB-R by leptin triggers downstream signaling through the JAK/STAT pathway. Leptin can homo-dimerize OB-R extracellular domains, initiating intracellular signaling events. Multiple isoforms of OB-R with different signaling capabilities have been identified. RNA transcripts of the OB-R long form are found in the choroid plexus and hypothalamus, key regions for satiety and energy regulation. Mutations in OB-R (db) or leptin (ob) genes cause early-onset obesity and metabolic abnormalities such as hyperinsulinemia, insulin resistance, and increased adipose tissue.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.