Thermo Fisher Scientific SNAIL Polyclonal Antibody
SNAIL 단백질을 인식하는 염소 유래 Polyclonal 항체로, Western blot 및 IHC(P) 분석에 적합합니다. 인간, 마우스, 랫트에 반응하며, 0.5 mg/mL 농도의 액상 형태로 제공됩니다. 암세포 EMT 및 E-cadherin 조절 연구에 유용합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–1 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (RKPSDPNRKPNY) corresponding to the N-terminus amino acids of SNAI1 (aa 8–19) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10987232 |
Product Specific Information
- This antibody is predicted to react with rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 64,000.
Target Information
Zinc finger protein SNAI1 (SNAIL) is a zinc finger transcriptional repressor that downregulates ectodermal gene expression within the mesoderm and functions in mesoderm and neural crest formation.
SNAI1 is a key factor in tumor invasion through E-cadherin downregulation and induction of epithelial-mesenchymal transition (EMT).
In human breast cancer, expression of SNAI1 and/or SNAI2 (Slug) has been associated with E-cadherin repression, metastasis, tumor recurrence, and poor prognosis.
Snail 1 protein in the stroma may be a potential prognostic marker for colon tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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