Thermo Fisher Scientific DR4 Polyclonal Antibody
Human DR4 단백질에 특이적인 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF 등 다양한 응용에 적합. 고순도 IgG fraction으로 정제된 액상 형태이며, 1 mg/mL 농도 유지. DR4 매개 세포사멸 연구에 활용 가능.
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Thermo Fisher Scientific DR4 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 427–445 of Human DR4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | IgG fraction |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2205071 |
Product Specific Information
- Recommended positive controls: Jurkat Cell Lysate (GTX27899), HepG2 Cell Lysate (GTX27900), Human Spleen Tissue Slide
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1.
The ligand for this DR4 death receptor, TRAIL, is a member of the TNF family.
DR4 mediates apoptosis and NF-κB activation in various cells and tissues.
Apoptosis, a programmed cell death, is an essential process in normal cellular differentiation and development.
It is induced by certain cytokines (TNF family—TNF, Fas ligand) and their death domain-containing receptors (TNFR1, Fas receptor).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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