Thermo Fisher Scientific Human NOTUM Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 19 amino acids near the amino terminus of human NOTUM.
PEP-0902 can be used as a blocking peptide with polyclonal antibody PA5-20788.

Target Information

Genetic studies in Drosophila have revealed a novel secreted antagonist for Wingless (Wg) signaling, referred to as Notum/Wingful (Wf). Wf/Notum encodes a protein of 430 amino acid residues, which is related to plant pectin acetylesterases of the α/β-hydrolase superfamily.
The main target of Notum action appears to be cell surface proteoglycans Dally and/or Dally-like (Dlp). Notum governs the extracellular Wg morphogen distribution via Dally and Dlp.
Like some vertebrate Wnt antagonists, notum expression is activated by Wg signaling, revealing a feedback control mechanism in which Wg modifies its own gradient distribution.
In vertebrates, proteoglycans related to Dally and Dlp likely play important roles in Wnt signaling, encoding a glypican required for Wnt-11 signaling. A single ortholog of Notum exists in the mouse and human genome, suggesting a similar regulatory mechanism in vertebrates.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.