Thermo Fisher Scientific Human NOTUM Synthetic Peptide
인간 NOTUM 단백질의 N-말단 19개 아미노산 서열에 해당하는 합성 펩타이드입니다. 항체 차단(Blocking) 실험에 사용 가능하며, 정제된 액상 형태로 제공됩니다. PBS(pH 7.2)와 0.1% BSA, 0.02% sodium azide를 포함하며 -20°C에서 보관합니다.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 19 amino acids near the amino terminus of human NOTUM.
PEP-0902 can be used as a blocking peptide with polyclonal antibody PA5-20788.
Target Information
Genetic studies in Drosophila have revealed a novel secreted antagonist for Wingless (Wg) signaling, referred to as Notum/Wingful (Wf). Wf/Notum encodes a protein of 430 amino acid residues, which is related to plant pectin acetylesterases of the α/β-hydrolase superfamily.
The main target of Notum action appears to be cell surface proteoglycans Dally and/or Dally-like (Dlp). Notum governs the extracellular Wg morphogen distribution via Dally and Dlp.
Like some vertebrate Wnt antagonists, notum expression is activated by Wg signaling, revealing a feedback control mechanism in which Wg modifies its own gradient distribution.
In vertebrates, proteoglycans related to Dally and Dlp likely play important roles in Wnt signaling, encoding a glypican required for Wnt-11 signaling. A single ortholog of Notum exists in the mouse and human genome, suggesting a similar regulatory mechanism in vertebrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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